The revolving doors of Holby City Hospital never stop turning and 2025 is another busy year for cast and character entrances and exits.
Here’s our guide to all the exciting new arrivals, shocking exits and surprise appearances taking place in BBC1’s medical drama in the new year.
We’ve divided this Casualty 2025 Who’s Who into five parts: New Arrivals, Leavers, Returning, Special Guests and Rumoured.

The first new arrival of 2025 technically makes her debut in 2024, but as it’s in the final episode of the year we feel it’s fair enough to include her here.
From the off-set Indie Jankowski (Naomi Wakszlak) makes a strong impression on paramedic boss Jan Jenning (Di Botcher) – both good and bad. She’s talented, top of her class and confident. However, this confidence veers into cocky arrogance which belies her on-the-job experience.
Indie Jankowski is played by Naomi Wakszlak, whose other credits include Back, Above the Clouds, Pennyworth and Doctors.

Surgeon Sean Redmond isn’t backwards when it comes to stating what he wants – something that doctor Rash Masum learns from the get-go when he and the newcomer literally collide in Holby ED. With neither of them looking where they’re going, Sean (Seth Somers) demands Rash (Neet Mohan) replace his broken phone. Then things get even more awkward when Rash’s cousin doctor Tariq Hussein (Manpret Bachu) reveals Sean is his new housemate.
Something tells us that Sean is going to be a major headache for Rash!